2 edition of Once-daily gentamicin dosing for the treatment of postpartum infections: a preliminary report found in the catalog.
Once-daily gentamicin dosing for the treatment of postpartum infections: a preliminary report
Written in English
|The Physical Object|
|Number of Pages||25|
The monitoring of therapeutic drugs involves measuring drug concentrations in plasma, serum or blood. This information is used to individualise dosage so that drug concentrations can be maintained within a target range. 1 Drug concentration at the site of action cannot be routinely measured, but the desired or adverse effects may correlate better with plasma or blood . Etiologies are similar to native valve infections 2 or more years post-op. EMPIRIC TREATMENT PLUS Gentamicin 1 mg/kg IV Q8H Viridans streptococci or S. bovis with PCN MIC Յ mcg/mL 6 weeks Ϯ Gentamicin 3 mg/kg IV .
Recommendations for the evaluation and treatment of fever in children generally use three different age groups: neonates from birth to 28 or 30 days of age,16, 17 young infants one to three months. Bradsher, R. W., Jr. and Snow, R. M. Ceftriaxone treatment of skin and soft tissue infections in a once daily regimen. Am J Med ;77(4C) View abstract.
Once-daily dosing and multiple-dosing with gentamicin both provide adequate serum levels, and either method has similar cure rates (Livingston, ). Because of potential nephrotoxicity and ototoxicity with gentamicin in the event of diminished glomerular filtration, some have recommended a combination of clindamycin and a second-generation. b.i.d.) or day (SOU nig/kg once daily) or vehicle (starch solu- tion 2%). At fetuses were explanted for skeletal evaluation. Postnatal studies were performed on rats treatcd from day 9 of gesta- tion until day 21 of lactation with either vehicle alone, indinavir or ritonavir ( mg/kg once daily).
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Systemic infections: 1 mg/kg IM or IV infusion (over 30 to minutes) every 8 hours-Duration of therapy: 7 to 10 days Life-threatening infections: Initial dose: 5 mg/kg IM or IV infusion (over 30 to minutes) per day, given in divided doses 3 to 4 times a day.
Background. Intraamniotic infection is associated with maternal morbidity and neonatal sepsis, pneumonia and death. Although antibiotic treatment is accepted as the standard of care, few studies have been conducted to examine the effectiveness of different antibiotic regimens for this infection and whether to administer antibiotics intrapartum or by: Once-daily dosing of gentamicin is appropriate given its proven efficacy in similar infections, ease of administration, theoretical improved eradication with concentration-dependent killing, and.
Aminoglycoside antibiotics have limited tissue distribution, are dependent on renal elimination, and have a narrow therapeutic index. Thus, careful selection of empiric dosing regimens and serum level monitoring are needed to ensure safety and efficacy of these drugs.
A once daily dose of gentamicin 5 mg/kg achieved a significantly higher peak SGL and safer trough than a twice-daily dose of mg/kg albeit about a. Introduction. Gentamicin (GM) is an aminoglycoside that is widely used in clinical conditions to fair clinical response.
It was isolated from Micromonospora inproving to be a breakthrough in the treatment of gram-negative (GN) bacillary infections, including those caused by Pseudomonas was introduced into parenteral usage in Endometritis is inflammation of the uterine lining.
It can affect all layers of the uterus. The uterus is typically aseptic. However, the travel of microbes from the cervix and vagina can lead to inflammation and infection.
This condition usually occurs as a result of the rupture of membranes during childbirth. Endometritis is the most common postpartum infection.
Tetracycline is recommended in guidelines as part of bismuth-based quadruple therapy (bismuth subsalicylate, metronidazole, tetracycline, and proton pump inhibitor for 14 days); however, dosing is not provided. 25 to 50 mg/kg/day PO in 4 divided doses (Max: mg/dose) is the FDA-approved dosage for other indications.
JOURNAL TOOLS. Get New Content Alerts. The treatment protocol for this intervention was continued from the existing MINI program, which included use of oral cotrimoxazole-p and gentamicin injection for possible infection in newborns. Gentamicins Subject Areas on Research.
- Levofloxacin mg IV q24h OR gentamicin 7 mg/kg/dose IV daily PLUS - Azithromycin mg PO/IV (IV for the first 24 hours, patient can be converted to PO after 24 hours) - Narrow coverage (ceftriaxone + azithromycin) OR levofloxacin if Pseudomonas is not.
General dosing, susceptible infection (Red Book [AAP] ): Infants, Children, and Adolescents: Mild to moderate infection: Oral: 5 to 12 mg/kg/dose; typically administered as 10 to 12 mg/kg/dose on day 1 followed by 5 to 6 mg/kg once daily for remainder of treatment duration; usual maximum dose for the total course: 1, to 2, mg.
An adult patient (weight 60 kg) has bacteremia suspected to be due to a gram-negative rod. Tobramycin is to be admin- istered using a once-daily dosing regimen, and the loading dose must be calculated to achieve a peak plasma level of 20 mg/L.
Assume that the patient has normal renal function. Bacterial infection—1–3 mg/kg/d in 3 divided doses to achieve a peak 5–10 mcg/mL and trough Once-daily treatment postpartum (5 mg/kg) Serum gentamicin levels were mg/L 2 days after discontinuation of the drug, the first ever report of measurable serum gentamicin resulting from topical administration.
Multidrug-resistant (MDR) Klebsiella pneumoniae represents an increasing threat to human health, causing difficult-to-treat infections with a high mortality rate.
Since colistin is one of the few treatment options for carbapenem-resistant K. pneumoniae infections, colistin resistance represents a challenge due to the limited range of potentially available effective antimicrobials. Show Summary Details. mg PO every 12 hours on day 1, then mg PO once daily.
For severe infections, mg PO every 12 hours. For sinusitis, clinical practice guidelines recommend mg PO twice daily or mg PO once daily for 5 to 7 days as second. The suggested dose is mg/kg once daily for preterm infants, 4 mg/kg once daily for newborn > 35 weeks of gestation and 5 mg/kg daily in two divided doses for neonates with severe infection.
4, 5 It is important to measure serum gentamicin concentrations when the drug is administered for more than 48 hours.
Acyclovir is approved by the Food and Drug Administration as a prescription drug that is commonly used as a topical, injectable, and oral treatment for genital herpes and cold sores. Herpes refers to a group of viruses that cause a variety of herpes infections including genital herpes, shingles, chicken pox (also chickenpox), cold sores, and encephalitis (inflammation of.
A Phase II, randomized, open-label, multicentre study demonstrated that sitafloxacin ( mg once daily) was as safe and as well tolerated as imipenem ( mg three times a day) for the treatment of pneumonia, including two cases of P.
aeruginosa pneumonia, one in each group. Aerosolized antibiotics.Read "A randomized, prospective study comparing once daily gentamicin with thrice daily gentamicin in the treatment of puerperal endometritis, American Journal of Obstetrics and Gynecology" on DeepDyve, the largest online rental service for scholarly research with thousands of academic publications available at your fingertips.Mitra AG, Whitten MK, Laurent SL, et al: A randomized, prospective study comparing once-daily gentamicin versus thrice-daily gentamicin in the treatment of puerperal infection.
Am J Obstet GynecolSoper DE, Kemmer CT, Conover WB: Abbreviated antibiotic therapy for the treatment of post-partum endometritis.